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In contrast to PDGF-BB, in diabetic wounds, induced by alloxan application, BPC 157 largely promoted mature collagen in granulation tissue (Seveljevic-Jaran et al., 2006) (note, previously, BPC 157 healed alloxan-induced gastric lesions in rats (Petek et al., 1999))
Research suggests they might work through sequential and complementary pathways: BPC-157 could provide initial cytoprotection and anti-inflammatory effects, creating a favorable environment for repair, while TB-500 might then promote cellular migration and structural reorganization
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